腎臓ドナーは非ドナーに比べて全体的な骨折が少ない

The incidence of all types of fractures in kidney donors was significantly lower than in controls.
Between donors and controls, there were 443 observed and 499.8 expected fractures.
The researchers found that although living kidney donors had a lower overall risk of fractures after donation, they had a significantly higher frequency of vertebral fractures compared to the control group.

A research team led by Hilal Maladit Kremers, MD, of the Mayo Clinic's Division of Epidemiology and Quantitative Health Sciences in Rochester, Minnesota, will evaluate interventions such as vitamin D3 to reduce vertebral fractures and patient morbidity. conducted a survey25. Several years have passed since the donation. This study compared the overall and site-specific risks of living donors with a matched general population control group.

Wrist fractures or osteoporosis
The incidence of any type of fracture in 2019 donors was significantly lower than in controls. Source: Adobe Stock.
"Living kidney donation is not without health risks," they write. Living donors “may be at increased risk of fracture due to kidney mass decreased, decreased serum 1,25-dihydroxyvitamin D concentrations, and secondary increases in serum parathyroid hormone.”

The study was conducted from 2021 to 2023 and included 2,132 living kidney donors and 2,014 control patients from Mayo Clinic, Hennepin County Medical Center, and University of Minnesota Medical Center. Participants (age 50 and older with at least 10 years since donation) completed a questionnaire regarding bone and fracture health. The primary outcome measures focused on overall and site-specific fracture rates between groups. Researchers completed their statistical analysis in August 2023.

Overall, 42 donors and 137 controls were excluded from the analysis due to incomplete survey data. Among the remaining patients, the total rate of fractures was significantly lower among donors, but the number of vertebral fractures within the group was significantly higher, Kremers et al reported. The incidence of all types of fractures in the 2,090 kidney donors was significantly lower than in the 1,877 control group, with 443 observed compared to the control group. There were more vertebral fractures in donors than in controls, with 51 observed and 36 expected vertical fractures.

"Although overall donor fracture rates were low, reduced kidney mass and long-term hyperparathyroidism may predispose living kidney donors to trabecular bone loss and vertebral fractures." write Kremers et al. " Treatment of excess vertebral fractures with nutritional supplements...may reduce their number."